Wednesday, May 30, 2012

Polish prime minister demands Obama address Nazi gaffe

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Cloture Club ? Senate Employment Bulletin for May 30, 2012

221622 ? MAIL PROCESS MANAGER?-

Senior Western Democrat seeks an experienced and highly motivated Mail Manager with excellent computer skills to supervise the mailroom in an extremely busy office. Principal duties include correspondence management, oversee mail flow for incoming and outgoing mail ? route correspondence dealing with casework, schedule and any misdirected mail, continually make improvements in mail flow, minimize issues, proof and approve all library items, oversee process for printing letters at local and offsite printers, modify and develop templates as needed, help answer Administrative mail, work with interns on processing LC mail, provide feedback and training when needed, develop custom reply library items when necessary, work with administrative team to improve database process and procedures, identify bugs and suggest future features to improve database, review database training documents, assist Database Manager with feature development, testing issues, etc., assist with development of procedures/instructions for LCs/Caseworkers for database/mail processes, assist staff with proper use of database and answer their questions, routine maintenance including filters and rules to control spam, check undeliverable emails and process as needed, check fax, scheduling, and Member?s Outlook mailboxes to ensure mail is being processed in a timely manner, process when needed, check Queued for Sending, Outbox, Prepared for Printing, and Reply in Progress mailboxes for correspondence and handle as necessary, prepare reports for status of pending mail and aging dates, and monthly correspondence report for Senator, back-up Mailroom Staff Assistant, Database Manager, and Computer Maintenance Assistant, complete administrative and database tasks as assigned. Familiarity with Symplicity voice computer system is a plus. Applicants must be able to work well in a fast-paced environment and have strong interpersonal, written, and oral communication skills, and the ability to analyze issues and monitor workload.?Please send cover letter and resumes to Baucus_manager@baucus.senate.gov

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Column: Winning's grand, entertaining is enough - WMCTV.com Home

By JIM LITKE
AP Sports Columnist

CHICAGO (AP) - The Cubs skulked back into town with their tails between their legs and plenty to answer for.

Then Monday dawned hot and hazy and by mid-afternoon, the sun was shining, the cold beer was flowing, the wind was blowing out and a fleet of baseballs hitched a ride on the jetstream over the walls at Wrigley Field. By the time the accounting was done, the Cubs had half of the eight home runs and an 11-7 win over the equally hapless Padres.

Throw in a pre-game flight by the eagle Challenger and a seventh-inning rendition of "Take Me Out to the Ball Game" by actor Brian Dennehy - in town starring in the play, "The Iceman Cometh" - and it was entertaining enough to send fans out the door wondering where the party was relocating and exactly what they were so upset about in the first place.

Cubs manager Dale Sveum wasn't about to remind them.

"Let's not kid yourself. You lose 12 in a row, you finally win. It's a big relief," he said afterward

Just don't count on celebrating for long. Even in bad years, the Cubs usually don't swoon until June. This year they couldn't even make it to Memorial Day. At this rate, they could be mathematically eliminated by the Fourth of July.

The last six of the Cubs' dozen straight losses came during a seven-day road trip at NL Central rivals Houston and Pittsburgh, two of the only half-dozen or so teams Chicago actually has a chance against. It was like being told to bring back dinner and spending all night at the bar instead, then returning empty-handed and praying fans hadn't changed the locks on the gates at Wrigley Field.

"Patience is something a lot of fans don't have," Sveum had said Sunday in Pittsburgh.

Yet he marveled the way Cubs fans had stuck by his team thus far.

"We all understand -- I'm a huge football fan and I don't understand the Oakland Raiders losing every game. That's the way it is."

In Chicago, maybe.

Even so, Theo Epstein wasn't inclined to press his luck. His title with the Cubs is president of baseball operations, but Chicagoans think of Epstein as the boy genius-general manager who ended the Red Sox' decades-long World Series drought and was brought to town to repeat the trick here. Never mind that he preached patience upon his arrival last October and despite his best efforts, still has only two everyday ballplayers - Starlin Castro and David DeJesus - who could start for most clubs, a barely adequate rotation and a mess in the bullpen.

Even Epstein made it sound like he didn't sign on for this.

"I think we're clearly better than this ... on both fronts, short- and long-term, there's work to do," he said at a hastily arranged news conference.

Unfortunately, though beyond "start scrapping and keep grinding for pride," Epstein was short on specifics on how to improve things over the short term.

"Long term," he added, not much more optimistic, "it underscores the magnitude of the job here and sort of how far we need to go to get where we want to be."

At a century and still counting, Cub fans are either the dopiest of most patient bunch in sports. And over the course of all that losing, they've learned to savor the distractions that are often more interesting than anything the team has been able to cobble together on the field. That's why they happily blame black cats, real goats and imaginary scapegoats like Steve Bartman for the ballclub's unending run of futility.

Winning is great, but in these parts entertaining is still good enough.

Last week's brouhaha was over whether Joe Ricketts, the conservative patriarch of TD Ameritrade and the family that owns the Cubs, was really planning to finance a nasty political attack campaign against President Barack Obama - and whether that would make it harder for the Cubs to gain concessions to modify Wrigley Field from the city's staunchly Democratic mayor, Rahm Emanuel, and the city council.

The week before that, it was the nostalgia kicked up by the retirement of one-time pitching phenom Kerry Wood and an essay in The Wall Street Journal calling for the destruction of Wrigley Field, suggesting the aging shrine was actually the reason for all that losing:

"Destroy it. Annihilate it. Collapse it with the sort of charges that put the Sands Hotel out of its misery in Vegas. Implosion or explosion, get rid of it. That pile of quaintness has to go. ... When a house is haunted, you don't put in a new scoreboard, add ivy, get better food or bigger beers_you move!"

Sounding more like a fan than the Cubs left-fielder, Alfonso Soriano considered the option for the briefest of moments.

"Leave this place? No, never," he said after going 3 for 4 with a homer and three RBIs. "You saw how much it was jumping when we got it going. Let's see what can happen now. We just had some tough moments before."

Which is, give or take a few years, is how the Cubs still refer to the last century.

___

Jim Litke is a national sports columnist for The Associated Press. Write to him at jlitke(at)ap.org and follow him at Twitter.com/JimLitke.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Tuesday, May 29, 2012

?The Avengers? Review | The Cinema Jack

DIRECTOR // Joss Whedon

PRODUCER // Kevin Feige

WRITER // Joss Whedon

CAST // Robert Downey, Jr., Chris Evans, Chris Hemsworth, Mark Ruffalo, Tom Hiddleston, Jeremy Renner, Scarlett Johansson, Samuel L. Jackson

B

Marvel? Studios has been building up to The Avengers since it was first teased in a post-credits scene in 2008?s Iron Man. Four films later, one of the most anticipated films of the past decade has finally hit big screens nationwide, and fan reaction has been more than generous. The Avengers is the fourth-highest-grossing film of all-time, the highest-grossing comic book adaptation, the highest-grossing superhero film, and the highest-grossing film produced and distributed by Disney. Much like its hype, The Avengers itself is a massive spectacle of a film, expensive and shiny and beautiful to look at, but it fails to do much beyond tantalizing the eyes and the ears.

The opportunity to witness a group of prolific superheroes gather in a single film is an enticing concept, and seeing Robert Downey, Jr.?s Iron Man, Chris Evans?s Captain America, Chris Hemsworth?s Thor, and Mark Ruffalo?s Hulk does inspire excitement and star-struck awe, but their interactions are exactly what anyone with a half of a brain cell would expect. Critics have praised the fact that these heroes do not get along initially, but would any mentally competent human being expect any different? Each character is expressed through the single punchline they are given: Tony Stark is an egotistical narcissist (more annoyingly so than he was in Iron Man and Iron Man 2), Thor is a fish out of water that does not understand human culture, Captain America is behind on the times, and Hulk is an angry green man; all of these heroes are played for laughs and none of them have any serious character traits.

That gripe is part of the film?s largest problem: the script. Writer-director Joss Whedon is and always has been a talentless hack, unfit to properly pen my order at a restaurant, let alone a big Hollywood adaptation of such a beloved property. His writing is massively and annoyingly pretentious; ?he wants you to know just how clever he thinks he is. I cannot think of a single point in the film that properly sustained a solemn or tense atmosphere for more than a couple minutes before Whedon butted in and tried to be funny. If I wanted to hear obnoxious and snarky dialogue, I would go into a cave and speak with my own echo, but I am not a cave-dweller and Joss Whedon is not as clever a screenwriter as he boasts.

Fortunately, his direction is not nearly as abysmal as his writing. Whedon does stage a number of aesthetically impressive action sequences, specifically a drawn-out battle in Manhattan. Each Avenger contributes his or her own unique ability, and when Mark Ruffalo becomes The Incredible Hulk, mass destruction ensues when Whedon isn?t trying to make some sort of mockery of it. The Manhattan melee is a cornucopia of creative camera shots and stunning special effects, but even beautiful people doing the most beautifully explosive things imaginable cannot save a script that a thirteen-year-old class clown could write in his sleep.

Back in 2005, Christopher Nolan surprised audiences everywhere with Batman Begins, a film that took a ridiculous premise and made it gritty and realistic. As opposed to doing something like that, Joss Whedon has instead decided to make no effort in writing a good script, but rather write about how stupid the film is, and, to his credit, his assertion of its stupidity is fairly accurate. Is The Avengers a bad film? No. Is it a great film? No. I enjoyed it for what it was: manufactured explosions and high-grade effects. It?s a sadly disappointing film, and perhaps with better writing, it could really have achieved greatness, but as it stands, The Avengers is a serviceable popcorn flick that works as a decent kick-start to the summer movie season.


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ABC Family BUNHEADS Screening!

We are so excited to offer our readers the opportunity to screen the pilot of the new ABC Family show, BUNHEADS!You guys will get to see it before it premieres!   I am super excited about this show for a few reasons – summer tv has been show and this show seems like it will be a fun show to watch, and it is from Executive Producer Amy Sherman-Palladino, the creator of Gilmore Girls, which I LOVED! Although, I hated the ending of the series lol. Here is a synopsis of the show: Bunheads is the tale of a Las Vegas showgirl, who impulsively marries a man, moves to his sleepy coastal town, and takes an uneasy role at her new mother-in-law’s dance school. From Executive Producer Amy Sherman-Palladino, the creator of Gilmore Girls, the series will be headlined by Tony Award winning actor Sutton Foster. Bunheads is set to premiere Monday, June 11. They aren’t giving much more away but Right Celebrity has the exciting opportunity to let 4,000 of our readers view it. This will be available until June 3 and it is first come first serve. Here is the magic info you need! Case-Sensitive Code: RightCelebrityBunheads ? [...]

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$488900 :: 17764 Kelok RD, Lake Oswego OR, 97034 ? Lake ...

4 beds, 3 full baths
Home size: 2,742 sq ft
Lot Size: 22,215 sq ft
Property Type: DETACHD
MLS Number: 12664857
Community: Lake Haven

Welcome Home?..Over 1.2 acre level fenced yard with great plantings. Location is short distance to award winning Lake Oswego schools,parks and shopping. Large family room that opens to a deck and yard.There are 3 Lake easement deeded to house.Updated 4 bedrooms and 3 full baths, lots of space to relax or entertain. This is a home you will not want to miss!

Listed with John L. Scott


Brought to you by Chris Larsson, Coldwell Banker Seal. Call me today at 503-683-2897!

The content relating to real estate for sale on this web site comes in part from the IDX program of the RMLS? of Portland, Oregon. All real estate listings are marked with the RMLS? logo, and detailed information about these properties includes the names of the listing brokers. Listing content is ? 2009 RMLS?, Portland, Oregon.


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Let me help you find everything you need to know about buying or selling real estate in Lake Oswego, OR! I have been a top-producing Coldwell Banker real estate professional for over 8 years in LO. I am 120% dedicated to providing world-class concierge level service to my clientele.


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Monday, May 28, 2012

Trainer says boxer Williams paralyzed in US crash

(AP) ? Boxer Paul Williams was paralyzed from the waist down Sunday after being involved in a motorcycle crash in the Atlanta suburbs and doctors said it is unlikely he will continue his career, his manager, George Peterson said Monday.

"From the waist down, he has absolutely no movement. He's in very good spirits, though," Peterson told The Associated Press from his home in Aiken, South Carolina. "He still believes he's going to fight again."

Williams severed his spinal cord after falling on his back and head when he was thrown from his motorcycle Sunday morning in Marietta, Georgia, Peterson said. Williams has been listed in serious but stable condition on Monday at an undisclosed hospital.

"I know he's going to make a statement after surgery on Wednesday, because he's that kind of person," Peterson said. "He's 100 percent coherent and still has the will to want to get back on the motorcycle."

Williams was scheduled to fight Saul Alvarez on Sept. 15 in Las Vegas but that event has been canceled, Peterson said.

He said he continues to hope with Williams that the boxer's career isn't over.

"I want to think along with him, 'cause I've seen him do things in his boxing career that shouldn't have happened," he said.

The crash happened Sunday morning in Marietta after Williams tried to avoid another car in the next lane that was negotiating a curve and then had to maneuver to avoid an oncoming car. Williams was in the area to attend his brother's wedding Sunday afternoon, Peterson said.

"We want his fans to know he's going to be all right and he'll be back," Peterson said. "He said if he wasn't going to be boxing, he's going to be a stand-up comedian."

Associated Press

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Cynthia Nixon marries longtime girlfriend

By Reuters

Paul Morigi / WireImage

Christine Marinoni and Cynthia Nixon

Former "Sex and the City" actress Cynthia Nixon married longtime girlfriend Christine Marinoni in New York over the U.S. holiday weekend, her representative said on Monday.

"On May 27, 2012, Cynthia Nixon and her girlfriend, Christine Marinoni, were legally married in the state of New York," her spokeswoman said in a statement.

No further details were released.

Nixon, who found fame playing Miranda Hobbes on the hit HBO television show "Sex and the City" about single women navigating life, love and careers in New York City, has more recently appeared on TV programs such as "The Big C."

She and Marinoni have been together for around eight years, and they became engaged in 2009 at a rally supporting same-sex weddings in New York. They have one son together.

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Homecoming buzz: short-haired bees return to UK

(AP) ? A conservationist says she is releasing 100 short-haired bees into the wild, 20 years after they were wiped out in the British countryside.

The bees' population has declined dramatically across Europe in the last two decades as their habitats were destroyed.

They were declared extinct in Britain twelve years ago, however a colony had survived in southern Sweden.

Nicky Gammans told the AP she collected the bees in April, and held them in quarantine for several weeks before releasing them into the wild Monday in a nature reserve in Dungeness, Kent in southeast England.

She says she hopes the bees will feed off red clover flowers in the reserve and spread to the rest of the country.

Associated Press

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NFL's head injuries raise concerns with youth football parents

Already uneasy about the idea of letting her 7-year-old son Jason start playing tackle football, Elizabeth Giancarli made up her mind when former NFL star Junior Seau committed suicide.

While many of her son's friends are moving on to tackle, he'll be playing another year of flag football.

"I just couldn't put him in tackle football, only because of everything that's been going on," Giancarli said. "I think that the Junior Seau suicide really hit home, too. So we decided to put him in another year of flag, because the impact is significantly less."

Giancarli hasn't ruled out the possibility of letting her son play tackle when he gets older. But she hopes he won't want to.

"I hate to take that experience away from him, especially since we all love the game so much," Giancarli said. "But I just don't know if it's worth it."

That's a tough thing to say for Giancarli, a Tampa Bay Buccaneers season-ticket holder who drives all the way from the Fort Lauderdale area to attend games. But she's among parents nationwide who have felt compelled to reconsider whether football is safe enough for their children amid a steady flow of reports on the potential long-term effects of repeated head injuries, an ever-growing list of concussion lawsuits filed by former NFL players against the league, and the New Orleans Saints bounty controversy.

Plus, now, the death at age 43 of Seau, a star linebacker for two decades.

Although it is not clear why Seau killed himself earlier this month, his death advanced what already was an uncomfortable national conversation about the hidden consequences of playing football.

And while it is too early to establish a link between parents' safety concerns and football's popularity, there are indications that fewer kids across the country are putting on pads.

Research from the National Sporting Goods Association indicates overall football participation across all age ranges has decreased from 10.1 million in 2006 to 9 million in 2011, with the most significant drops in the 12-17 and 18-24 age groups.

According to the National Federation of State High School Associations, the number of high school boys playing 11-man football rose from 886,840 in 1992-93 to 1,112,303 in 2008-09. But after 16 years of nearly uninterrupted growth, the number of players has declined slightly during the two most recent years for which data was available: to 1,109,278 in 2009-10 and 1,108,441 in 2010-11. The number of youths participating in less common forms of the game - 9-player, 8-player and 6-player football - also fell slightly in the two most recent years available.

The decline doesn't appear to be a function of school budget cutbacks. According to the NFHS data, the number of high schools offering 11-player football continues to increase.

NFHS director of sports and sports medicine Bob Colgate says the small decline hasn't raised red flags among high school sports administrators and may be the result of normal fluctuation in class sizes.

Dr. Michael Koester, a pediatric sports medicine specialist in Eugene, Ore., who has advised the NFHS, says it's too early to connect a downward trend with parents' safety concerns - but says the numbers are worth watching, especially in youth football.

"I think it would be difficult to read anything into that at this point," Koester said. "I think we really have to look at what those high school numbers do over a four- or five-year period of time. And maybe more importantly at this time would be trying to get an idea from Pop Warner, from USA Football, see what's happening at the lower levels. I think if we're going to see a culture shift from a participation standpoint, I suspect that we're going to see it more at those lower levels, where parents are going to be deciding there's just no reason for their 7-, 8- or 9-year-old to be out there playing.

"And frankly, I support them in that. My son didn't start playing until he was 12."

USA Football says participation in youth football has been relatively stable in recent years, at about 3 million kids - but USA Football executive director Scott Hallenbeck acknowledges that may change, given parents' concerns about safety.

"My sense of it is, we're going to see a drop in participation," Hallenbeck said.

Hoping to ease those concerns, USA Football - a national organization founded by the NFL and the NFL Players Association - has put safety measures in place in recent years for the youth leagues that have joined its membership. USA Football-affiliated coaches must take a training class and pass a test, then follow specific instructions that include proper equipment fitting, an age-specific approach to teaching tackling and other techniques, and limits on contact in practice.

This fall, USA Football will launch what Hallenbeck believes is the first comprehensive study on injuries in youth football.

"Clearly, there's a concern, and we have been proactive on that for five or six years," Hallenbeck said.

Dr. Shayne Fehr, a pediatric/adolescent concussion specialist at Children's Hospital of Wisconsin, said more parents are expressing safety concerns to him.

"I had a patient this past week, he came in with his second concussion," Fehr said. "I believe he was about 14 years old, and his mother said - before he even got a chance to talk - that he's done with football."

Yet Fehr also said such dramatic declarations are rare.

"You have to remember that a lot of times, these families have grown up with sports such as football," Fehr said.

Former NFL quarterback Kurt Warner caused a stir recently when he said he worried about his own children playing football, but he's not the only ex-pro with reservations. For ex-NFL safety Matt Bowen, there aren't easy answers when it comes to balancing safety concerns against the positive things kids can learn from football.

"But I've had this conversation with my wife quite a bit, and I know in our house, our boys aren't going to play youth football," Bowen said. "My wife's already taken care of that. That's just not going to happen."

Bowen, who now writes columns for the Chicago Tribune and the nationalfootballpost.com website, gets a lot of questions from fellow fathers.

"I tell them that I love the game," Bowen said. "I respect everything I learned from the NFL, and in college and in high school. I don't think there's a better sport out there in terms of teamwork. I really don't, in terms of learning how to deal with some adversity that you deal with in real life. But I also tell them I got beat up a lot, had a lot of injuries. People ask about concussions all the time. 'What do you think? What's your stance on it?' A lot of times I just change the discussion. You're out drinking beer with some dads and they ask you, you talk about it a little bit. Yeah, I think it's violent. I think it's violent and I think it's made for young men, not little boys."

Kia LaBracke experienced that violence firsthand when her son, Nico, sustained a concussion from a big hit he took while returning a punt in a freshman football game in Oconomowoc, Wis. last fall. It took him months for him to recover and return to school full-time, leaving LaBracke and her husband, John, to make a difficult decision: They weren't going to let him play again.

"We knew it was going to be very tough," LaBracke said. "Because he's very dedicated to the sport, he's a very hard worker. This was his thing. A lot of his identity, who he was and who he is, was tied up in that."

LaBracke, who had a working knowledge of concussion issues through her job as the executive director of the Wisconsin chapter of the American Academy of Pediatrics, said her son didn't take the decision well.

"On an intellectual level, of course he understands," LaBracke said. "He would never say that, but of course he understands it. But I still don't think he's quite let go of the feeling that this is really unjust."

Now Nico's younger brother, Jack, is playing.

"But we've told him flat-out, we don't know how long this is going to last," LaBracke said. "We may cut this off at any point. And he understands it, because he watched what his brother went through. He was there when Nico came home and didn't know who his own brother was. I don't think he would be surprised if we pulled the plug at any point."

Chicagoan Erin O'Leary has told her 7-year-old son, Liam, that he can't play tackle for now. And she's hearing similar thoughts from fellow parents.

"Some of them are just like, 'Oh, well, they don't hit that hard at this age and it's not a big deal,'" O'Leary said. "But some like me, you keep seeing things on the news, reports that are released, and it is cause for concern. I mean, sports are great. I think there's a definite place for them, but long-term brain damage is not worth it. They have a long life ahead of them to do a lot of things."

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Sunday, May 27, 2012

The Healing Power of Physical Therapy

People who suffered from physical trauma or experiencing major pains in different areas of the body can count on physical therapy Shelby NC for long-term restorative relief. Physical therapy is has been practiced long before the world of medicine gave it a name. It aims to re-establish the body?s normal functioning, to better mobility, and recreate a normal self after any tragic incident. There are many types of physical therapy. Patients who want to experience its healing power may visit a reputable physical therapy center. Most PT centers in Shelby are known for their competent line-up of services such as wellness coaching, rehabilitation, occupational therapy, aquatic therapy, sports, training, low back and neck pain relief, among many others. It is not advisable to delay the healing of pain or injuries, internal and external. Time is of great importance. At one point or another, the injuries would manifest which can be prevented had you taken the time to seek a physical therapist.

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Saturday, May 26, 2012

Matthew McConaughey pulls off Cannes double header

Actor Matthew McConaughey poses during a photo call for Mud at the 65th international film festival, in Cannes, southern France, Saturday, May 26, 2012. (AP Photo/Jonathan Short)

Actor Matthew McConaughey poses during a photo call for Mud at the 65th international film festival, in Cannes, southern France, Saturday, May 26, 2012. (AP Photo/Jonathan Short)

From left, actors Macy Gray, Matthew McConaughey, director Lee Daniels and actress Nicole Kidman attend a press conference for The Paperboy at the 65th international film festival, in Cannes, southern France, Thursday, May 24, 2012. (AP Photo/Virginia Mayo)

El actor Matthew McConaughey y el director Lee Daniels durante una conferencia de prensa de la pel?cula ?The Paperboy? en el 65to Festival de Cine de Cannes, en Francia, el jueves 24 de mayo de 2012. (Foto AP/ Virginia Mayo)

From left, actors Jacob Lofland, Reese Witherspoon, Matthew McConaughey and Tye Sheridan pose during a photo call for Mud at the 65th international film festival, in Cannes, southern France, Saturday, May 26, 2012. (AP Photo/Joel Ryan)

Actors Reese Witherspoon, left, and Matthew McConaughey pose during a photo call for Mud at the 65th international film festival, in Cannes, southern France, Saturday, May 26, 2012. (AP Photo/Joel Ryan)

(AP) ? To have one film competing at the Cannes Film Festival is a privilege. To have two, Matthew McConaughey says, is wonderful good fortune ? and the reward for a spell of hard labor in the trenches of independent cinema.

In Lee Daniels' steamy Southern noir "The Paperboy," McConaughey plays a journalist who returns to his Florida hometown to investigate a murder.

In Jeff Nichols' "Mud," which screened Saturday as the festival's final competition entry, he is a story-spinning fugitive holed up on an island in the Mississippi who is befriended by two local boys.

McConaughey laughs when asked if having two movies competing for the Palme d'Or gives him divided loyalties.

"That would be a high-class problem," he said. "I'm really, really endeared to both of them for different reasons ? and they're very, very different from each other.

"I'm very honored. I've got two films that I'm proud of, two experiences that I really loved, and I've got two characters that I really care about."

The two films take the Texas-born actor on a tour of the U.S. South ? and of men on society's margins.

In "The Paperboy," McConaughey's Ward James is a crusading reporter with dark depths to his psyche that imperil his quest for the truth.

His title character in "Mud" is being hunted as a dangerous fugitive, but may be a wild innocent driven by love.

Critics have hailed McConaughey's turn in "Mud," and director Daniels said he was wowed by McConaughey's nuanced performance in "The Paperboy."

"I'm so happy that he's so understated in the film," Daniels said. "There were moments when I didn't recognize Matthew."

McConaughey said the roles were the result of a decision to "shake things up" in a career that has seen him take leads in a mixed bag of romcoms ("Failure to Launch," ''Fool's Gold") ? and, as he noted at Cannes, play lots of lawyers, in films from "A Time to Kill" to "The Lincoln Lawyer."

"I was looking for some characters that didn't necessarily pander to convention, or even didn't pander to plot," he said, long legs stretched out on a sofa in a Cannes hotel. "They're all kind of characters that live on the fringe, on the outskirts of society. But they're really human characters.

"What I was really looking for is some things where I could hang my hat and be the architect of my man, and it's based on humanity and reality. It's not based on morality or on good or bad or right and wrong."

That's where the similarities end between his two Cannes films. "The Paperboy" takes a Pete Dexter crime novel and mixes in director Daniels' fascination with shifting sexual and racial allegiances.

In "Mud," Arkansas-born director Nichols creates an affecting coming-of-age story with echoes of Mark Twain, rooted in the landscape of his home state.

"Lee is very different from Jeff Nichols," McConaughey said. "Lee's not a linear thinker at all. Jeff Nichols was very linear ? he wrote the script, wrote each word on purpose, and would be editing in his head after he thought he'd got his take.

"Lee grabbed this book but created his own world."

McConaughey's Cannes double-header is the product of remarkable year of work that saw him shoot five independent films with strikingly different directors.

As well as "The Paperboy" and "Mud," he was a sheriff in Richard Linklater's dark comedy "Bernie," a club owner in Steven Soderbergh's male-stripper movie "Magic Mike" and a hitman in William Friedkin's thriller "Killer Joe."

The 42-year-old actor has never been busier ? or, it seems, happier.

"I fired out of bed every morning so excited, and a little scared about going to work, but excited to go and get into it," he said. "I love the energy of an independent film. Time is so precious. There's no go-back-to-the-trailer time. It's a very vital experience, and I like that."

It was also an education in modern American cinema from five filmmakers with strong personal styles.

"Friedkin, you'd do one take, maybe two," McConaughey said. "Usually one. Soderbergh: minimalist. He's more of a shaper.

"With Linklater ? this was our third time working together. We do all this character work together. ... We have a shorthand together."

McConaughey will find out Sunday, when the film festival wraps up, whether either of his Cannes films has taken a prize.

Next up, he hopes, is "The Dallas Buyers' Club," a drama based on a true story about illegal AIDS drugs in the 1980s that he's long sought to make with director Jean-Marc Vallee.

"I never had a rule on what to do, just keep trying to do different things," he said. "But it's got to be more than that. I was instinctually drawn to this kind of material where I was not necessarily drawn to some other comedies or things that I've done in the past.

"I'm more fulfilled with the work probably than I've ever been, and more turned on by it, and I hope that continues."

___

Jill Lawless can be reached at http://Twitter.com/JillLawless

Associated Press

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Memorial Day: Remembering fallen of decade at war

Most people run marathons to challenge themselves. Maj. George Kraehe runs them to challenge others.

As a member of the Tragedy Assistance Program for Survivors' "run & remember team," the New Mexico Army National Guard officer has participated in 20 races. Most times, as he sweats his way along each 26.2-mile course, flapping against Kraehe's back is the laminated photograph of a service member who has died in what has become our nation's longest war.

The 46-year-old military lawyer from Albuquerque does it to raise money, but also "to be kind of a visible sign that there still are people out there fighting and dying, unfortunately, in these conflicts."

"Because I don't think it's something that is foremost in people's thoughts," he said in a recent telephone interview from Kabul, Afghanistan. "I think you could say that because we have done so well, because we have been a big part of preventing another attack on U.S. soil, it is easier for people to forget we're here."

As the nation approaches its 11th Memorial Day since the United States launched the Global War on Terror, Kraehe and others fear many have done just that.

About 2.2 million U.S. service members have seen duty in the Middle Eastern war zones, many of them veterans of multiple tours. And more than 6,330 have died ? nearly 4,500 in Iraq, and more than 1,840 in Afghanistan.

But as striking as those numbers are, fewer Americans today may have a direct connection to the ongoing fighting than during any previous war.

Unlike World War II, when 16 million men and women put on a uniform, less than 1 percent of the nation's population serves in the U.S. military. And unlike Korea or Vietnam, when the threat of imminent draft hung over the head of every physically fit male over the age of 18, only those who have volunteered need worry about being plucked from their routine lives and placed in harm's way.

When retiring Adm. Mike Mullen addressed the West Point graduating class last May, the outgoing chairman of the Joint Chiefs of Staff told the new Army officers that he believed most Americans appreciated the military's sacrifices. But, he added, "I fear they do not know us. I fear they do not comprehend the full weight of the burden we carry or the price we pay when we return from battle."

In a survey released shortly after the 10th anniversary of the 9/11 attacks, the Pew Research Center found that 84 percent of recent veterans felt the general public has "little or no understanding" of the problems they and their families face. Of the civilians polled, 71 percent agreed.

The same study found that only a third of Americans between the ages of 18 and 29 had an immediate family member who had served in the military. When she unveiled a special Gold Star Christmas tree at the White House last year to honor the families of fallen service members, first lady Michelle Obama lamented, "Not every American knows what a . Gold Star family is."

"I've had people say to me, 'Oh. We still have troops in Afghanistan?'" says Ami Neiberger-Miller.

The gold star license plate on her car is for her kid brother.

Army Spc. Christopher T. Neiberger was standing in a turret, manning the .50-caliber machine gun, during a run through Baghdad when an improvised explosive device blew apart his Humvee. It was Aug. 6, 2007 ? three days after his 22nd birthday.

While those who've lost someone to these wars are not as numerous as in her grandparents' generation, the proliferation of memorial T-shirts, car decals and even tattoos makes the survivors more visible, says Neiberger-Miller.

"I would hope that those things would invite questions," she says. "And what is surprising is how often they don't."

One difference between this war and, say, World War II is that shared sense of purpose, says Neiberger-Miller, a spokeswoman for TAPS.

"My grandparents have stories about rationing and sacrifice and having a victory garden ? all of those things Americans did for the war effort," she says. "Here, it's just a different environment. I don't think people feel they've been asked to sacrifice as a group for the war effort."

The profound sacrifice of losing a loved one in service to flag and country carries its own complexity. As part of this fraternity of sorrow, survivors like Neiberger-Miller are stuck in a sometimes awkward limbo: wanting people to honor their fallen, but needing to set boundaries.

Chris Neiberger is buried at Arlington National Cemetery, in Section 60. During a recent visit, his sister was sitting silently in front of his gravestone when a walking tour came by.

Although making a point of not engaging the tourists, she politely answered a couple of questions. When a woman approached to hug her, Neiberger-Miller stepped aside and shook her hand instead.

"I mean, they WANT to connect," she says. "They want into that world, but they DON'T want into it."

Rachel Ascione thinks people are aware of what's going on. They often just don't know how to show it.

Her stepbrother, Marine Cpl. Ronald R. Payne Jr., of Lakeland, Fla., died May 8, 2004, when his patrol came under fire from rocket-propelled grenades while searching for a Taliban official outside Kandahar in southern Afghanistan. Just 23, he was the Corps' first combat casualty in that country.

Ascione ? whose mother married Payne's father when the kids were in kindergarten together ? has a sticker on the back window of her car memorializing her brother. Sometimes, she will emerge from a store or restaurant to find a note from a stranger, "thanking me for my brother's sacrifice."

She recently hung out with a friend of Ron's who'd just returned from a stint as a medic in Afghanistan. He told her people here at home have no idea how bad things are.

"The longer we're there, the more people are dying," the 30-year-old Cranford, N.J., woman says. "Ultimately, everyone will know someone."

Maj. Kraehe, the marathon runner, is trying to help the rest of us "know" some of these fallen heroes.

In civilian life, Kraehe is an assistant U.S. Attorney, husband and father of two boys. When he puts on his uniform with its oak leaf insignia, he is a member of the Judge Advocate General's Corps.

Kraehe learned about the TAPS running program in 2006, during his first deployment, in Iraq. That December, he ran his first memorial race, whimsically dubbed the Honolulu Marathon "Forward." Kraehe and about 200 others ran through the flat desert along the perimeter of Contingency Operations Base Speicher, just north of Tikrit.

He did it in honor of CW2 Ruel Garcia, 34, of Wahiawa, Hawaii, who was killed Jan. 16, 2006, when his AH64D Apache helicopter was shot down over Baghdad.

In 2009, Kraehe made a decision: to run marathons in all 50 states, honoring a native son or daughter in each.

So far, he's made it to races from Arkansas (the Hogeye Marathon) to Wisconsin (the Madison Marathon), and "Rock 'n Roll" runs in both New Orleans and Las Vegas. And although his second deployment ? this time to Herat in western Afghanistan ? has made achieving his objective more difficult, Kraehe still finds time to honor his fallen comrades.

In October, he hitched a ride on a C-130 cargo plane to run a marathon in Kabul.

A day before the race, a suicide bombing in the city killed seven Americans. So he and the other two dozen participants were confined to the embassy compound.

"The course was a .9-mile loop," he says with a laugh. "So we were just kind of running around in a circle."

Twenty-eight times.

Last month, while home on R&R, Kraehe decided to run the Boston Marathon.

Normally, TAPS hooks him up with the family of a fallen service member and obtains a photo. But the organization was unable to find someone in time, so Kraehe chose a young man who'd been killed where he is now serving.

On Sept. 28, Army Spc. Steven E. Gutowski of Plymouth, Mass., was part of a four-person team clearing roads of bombs in Afghanistan's Ghazni Province. The combat engineer and two others were killed when an IED exploded.

In Boston, when Kraehe began to flag under the day's record heat, he reflected on why he was there.

"They didn't quit," he says. "They gave it their all, literally."

The 24-year-old soldier's mother didn't know of Kraehe's tribute until a reporter told her about it.

"It's overwhelming," Joan Gutowski said, her voice breaking. "These soldiers are unbelievable. They're a cut above everybody else, I'll tell you."

___

Online:

Maj. George Kraehe's fundraising page: htp://taps.kintera.org/faf/donorReg/donorPledge.asp?ievent(equals)333233&lis(equals)1&kntae333233(equals)451FDE8A149149A0842DD730D14991BA&supId(equals)330047141

Tribute to Cpl. Ron Payne ? http://youtu.be/lNCUBj1rR_A

Tragedy Assistance Program for Survivors: www.taps.org

___

Allen G. Breed is a national writer, based in Raleigh, N.C. He can be reached at features(at)ap.org.

Follow him on Twitter at http://twitter.com/(hash)!/AllenGBreed

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Friday, May 25, 2012

Online Chat Community

An online chat community can offer users the opportunity to make rewarding connections with others and even become part of a larger family of like minded communicators. Chatting on the Internet can take a number of forms including discussion forums or instant messaging. But the most frequently used definition will describe a group of people who communicate via text over websites that are geared for such purposes. There can be a number of different types of communities that are open for participation by interested Internet users. A general online chat community will be open to anyone, although there may be age restrictions. Unless the room has been designed especially for children, many sites will not allow participation by chatters who are under thirteen years of age. Some chat rooms and discussion forums may be created specifically for teenagers as well. A discussion board will allow users to read the content that other participants have posted, and add to the discussion if they choose to, or simply remain an interested bystander.

Often an online chat community will be created to cater to the needs of specific age groups or interests. For example, some rooms may be designed for teens and will have very strict age requirements. It can be difficult if not impossible to know for sure that a participating chatter is actually the age that they claim to be. Minors should be made aware of this fact and be careful about the information that they share and the kinds of conversations that they engage in while chatting. Some rooms may be designed for college students while other might be geared toward single adults. But even among single adults there may be certain age breakdowns. An online chat community will often not charge users for the privilege of chatting. But most websites of this nature will have certain rules of use regarding polite and appropriate behavior while chatting. Participants who violate these conditions may find that they have been banned from chatting on the site altogether.

A number of rules of etiquette will apply to participating in an online chat community. These rules of etiquette, or chatiquette, as they are sometimes called, rely largely on common sense and are similar to the rules that prevail in ordinary face to face conversations. Talking in all capitals is seen as the equivalent of shouting and is considered to be very rude. Flooding the screen with text is objectionable as well. Such behavior could mean that a chatter would be suspended or terminated from the chat room. One suggested code of conduct involves basic consideration for the other chatters in the room. One would never walk up in the middle of a face to face conversation and inject something totally unrelated to the discussion. In the same way, it'is considered very rude to jump into an Internet conversation without any regard for the ongoing discussion. It's best to hang back and get a feeling for what is being talked about as well as the general mood of the discussion before making a contribution.

Ignoring other chatters in an online chat community is not a good idea either. Just as this behavior is considered rude in the real world, it is also offensive in the virtual realm. When questions are posed by other chatters, a reply of some nature is generally called for. If another participant has an opinion that differs from other chatters, respect for that person's right to their own opinion is called for. When the time comes to leave the room, it's polite to say goodbye rather than to simply exit without notice. There can be a number of perils that might be associated with written communication. A chatter may assume that others in the group will recognize a bit of sarcasm, but this may not be the case. Since facial expressions are not visible, it's easy to be misunderstood in an online. Remaining positive and relevant to the discussion are also good rules of online communication. And it's always good to remember that no one appreciates a conversation hog.

In spite of the many benefits that are associated with an online chat community, there can be a few pitfalls as well. As with all relationships among human beings, there may be times when participants in a chat room do not get along. There have also been occasions when disagreements and misunderstandings have been taken to the extreme. Anger on the world wide web can spill over into the real lives of chatters. For this and many other reasons, it's very unwise to let a fellow chatter know personal details such as full names and physical addresses. Even personal email addresses should be kept private. Some chatting services will offer users the opportunity to use a separate email address through the service itself so that outside addresses may be kept private. The Bible encourages believers to let go of worry and to have faith. "Let not your heart be troubled: ye believe in God, believe also in me." (John 14:1)

A number of other safety issues should be observed in an online chat community. Meeting a fellow chatter in person is usually not a good idea, particularly for minors. There have also been reported incidents of crude language and inappropriate verbal behavior in some chat rooms. If this happens, participants should consult web masters or site facilitators and report the offending individuals. If used wisely and with common sense, these opportunities for communication on the web can be very fulfilling.

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To make an effect on prospective client and to ensure very good returns, advertisers don?t hesitate on advert spends. They may be assured that returns would be substantially superior. A successful advertising marketing campaign becomes obvious only when advertisements are placed correct and therefore are specific completely.

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Thursday, May 24, 2012

Anatomy Of A Perfect Landing Page [INFOGRAPHIC] - Feedgrids

There are some things money can?t buy; happiness, love, true friendship. For everything else, such as totally awesome hotel room, money will do the trick quite nicely. For a bill measured in tens of thousands of dollars a night, you can live in the lap of luxury with your own cook, butler and concierge while taking in the most amazing views from your private balcony. Hey, if you?ve got the cash, why not? Just in case you ever find yourself on receiving end of a hefty lottery win or d

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Syria assails rebel town, admits sanctions hurting

Syrian forces tried to storm the rebel bastion of Rastan on Wednesday under cover of heavy gunfire, shelling and rocket bombardment, reports said, as Damascus admitted sanctions were biting hard.

Meanwhile, the rebel Free Syrian Army (FSA) denied it was behind the abduction of Lebanese Shiite pilgrims, an incident stoking tensions in neighbouring Lebanon, divided between pro- and anti-Damascus camps.

There was no word on any Rastan casualties, but the Syrian Observatory for Human Rights said 15 people were killed nationwide, including seven troops shot dead at Qalamun in Damascus province as they tried to defect.

As the violence continued to rage, Russia, one of Syria's rare allies, offered to host direct talks between the Damascus regime and rebel representatives, Deputy Foreign Minister Mikhail Bogdanov said.

Soldiers were trying to overrun Rastan for the second time in 10 days, with shells crashing into the town at the rate of "one a minute" at one stage, according to the Britain-based Observatory.

An activist said FSA fighters were defending Rastan's entrances but that "regime forces are being strengthened with new deployments," including from the elite Republican Guard.

"Electricity has been cut off in Rastan, and water tanks have been shelled," Abu Rawan told AFP. "There is also a severe lack of food because the market is closed and we can't bring food in from nearby villages."

Hours later, the activist said the army assault eased when a team of UN observers entered Rastan.

"The situation is calm now because the UN monitors have arrived," having heard the shelling, Abu Rawan told AFP. "God protect us when they leave."

On May 14, 23 soldiers were killed in a failed assault on Rastan, a town straddling the main highway linking Damascus to the north and where rebels regrouped from the battered city of Homs.

Elsewhere, troops fired on protesters in second city Aleppo in the north as about 1,500 people rallied against the regime, triggering armed clashes, said the Observatory.

Activists said lawyers and sympathisers with the revolt staged a sit-in at Aleppo's judicial complex to demand the release of political prisoners, and to pay tribute to four students killed at a May 3 rally in the city.

The uprising against President Bashar al-Assad broke out with peaceful democracy protests in March 2011, prompting a fierce crackdown that spawned an increasingly militant response.

More than 12,600 people have been killed, nearly 1,500 of them since a UN-backed truce took effect April 12, according to the Observatory.

The bloodshed has persisted despite a ceasefire brokered by UN and Arab League envoy Kofi Annan, as well as previous diplomatic measures, including several rounds of sanctions against Assad's regime.

Oil Minister Sufian Allaw admitted on Wednesday that punitive measures imposed by the West have cost Syria almost $4 billion (3.2 billion euros) and caused shortages in fuel products.

"The oil sector has lost almost $4 billion because of the unjust European and US sanctions, blocking exports and imports of oil and oil derivatives," he told a news conference.

The minister acknowledged "new difficulties" in meeting Syria's energy needs, especially for domestic gas, blaming measures taken by the United States and the European Union.

Allaw said negotiations were under way with Russia for a long-term energy deal, while a Venezuelan vessel loaded with 35,000 tonnes of fuel oil docked in Syria this week and another expected soon.

Also on Wednesday speculation was rife among anti-regime activists over the alleged "killing" of Assad's brother-in-law Assef Shawkat, who is also Syria's deputy defence minister.

Shawkat, former head of military intelligence, was poisoned, according to anti-regime activists. The authorities in Damascus could not be reached for comment and have not responded publicly to the claim.

The raging violence took a broader turn in the region after Lebanon's state news agency said Syrian rebels kidnapped 13 Shiites as they were headed home to Lebanon by bus from a pilgrimage in Iran.

Lebanese Foreign Minister Adnan Mansur said the pilgrims were abducted by "a splinter group of the armed Syrian opposition", but added he expected their release "within hours."

The FSA denied involvement.

"The FSA is not at all responsible for the operation," Mustafa al-Sheikh, a high-ranking member of the rebel force, told AFP by telephone from Istanbul, blaming the regime for the abduction.

The opposition Syrian National Council also issued a call for the prompt release of the pilgrims, adding it too believed the regime could be involved in the kidnapping.

But Lebanese women pilgrims who arrived in Beirut on Wednesday said the kidnappers presented themselves as FSA fighters. "They terrorised us," one said.

The case has triggered fears of sectarian tensions in Lebanon over the Syrian conflict and on Wednesday hundreds of people staged a sit-in in support of the pilgrims in Beirut's mostly-Shiite southern suburbs.

Meanwhile, Russia and Saudi Arabia cautioned against an escalation of tensions.

And Google announced that its mapping software and other products would be available in Syria after getting export approval by the US government, citing the right to "free expression."

Over the past 14 months of unrest, pro-democracy protesters have used social networking sites to whip up support and the government has also resorted to the Internet to strike back.

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Juniper Invests in Video Conferencing Startup Vidyo ? Techno Capital

Juniper Networks? investment in video conferencing company Vidyo represents the latest move by a networking vendor to add video capabilities to its portfolio.

Vidyo officials announced May 22 that Juniper, through its Junos Innovation Fund, was investing in the company, and that the plan is to integrate Vidyo?s video collaboration technology with Juniper?s product lineup. Juniper?s investment was announced as part of Vidyo?s Series D round of funding, though company officials did not say how much Juniper is investing.

Vidyo over the past few years has raised $97 million, and officials said in September that the company had raised $22.5 million as part of its Series D round.

Cisco Systems and Polycom are the top vendors in a video conferencing market that analysts expect will continue to grow as businesses look for ways to improve employee productivity, enhance collaboration with workers, partners and customers, and reduce operating expenses, including travel costs. The increased mobility of the workforce is also driving the need for greater video capabilities across multiple devices, including laptops, smartphones and tablets. Analysts with market research firm IDC are predicting that the worldwide enterprise video conferencing market, which hit $2.7 billion last year, will grow to $3.2 billion in 2012.

The market also has become increasingly competitive, with Cisco and Polycom being pressed by smaller rivals looking to offer more cost-effective alternatives that offer the same performance capabilities.

In addition, networking and unified communications (UC) vendors also are looking to add video capabilities to their product lineups, either through in-house development, partnerships or acquisitions. For example, Avaya in March announced plans to buy Radvision, a video conferencing company that had fallen on hard times since partner Cisco bought rival Tandberg for $3.3 billion in 2010.

Alcatel-Lucent in July 2011 rolled out its own offering, the Visual Collaboration suite, a combination of home-grown technology and partnerships.

Juniper itself in 2010 announced a partnership with Polycom, but little appeared to come out of that alliance. Now the networking company is turning to Vidyo.

?As the use of video in the enterprise and on end devices continues to expand, our customers are seeking new ways to improve video delivery,? Jeff Lipton, vice president of venture and strategic investments at Juniper, said in a statement. ?Vidyo is an emerging player that is driving innovation in software-based videoconferencing, and we believe its leading technology will improve the experience and economics of video communications alongside advances in networking technologies.?

Vidyo has seen significant growth over the past year. The 225-employee company in April announced 82 percent growth in billings over the previous year, which came at a time when both Cisco and Polycom saw disappointing first-quarter numbers for their video collaboration businesses. Vidyo officials said the company has more than 1,850 customers, not only in the enterprise, but also in health care, education and government.

The company offers a software-based solution that includes the VidyoRouter platform that brings video conferencing to multiple devices, including smartphones, tablets, PCs and telepresence systems. Vidyo introduced a virtualized version of VidyoRouter in March. Last year, the company unveiled Vidyo Panorama, which officials said brings high-quality video conferencing at a much lower cost than room-based systems from Cisco and Polycom.

?Juniper Networks? strategic investment in Vidyo is a solid endorsement of our vision and a recognition of how rapidly the videoconferencing market is expected to grow in the near future,? Vidyo founder and CEO Ofer Shapiro said in a statement. ?We see Juniper as a kindred spirit, itself a pioneer in its industry, having revolutionized networking for over 16 years.?



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And the winner of 'Dancing With the Stars' is ...

By Ree Hines

As a football pro, Donald Driver knows a thing or two about how to play a game. It doesn't matter if you're down in the first half -- or even the first three quarters. What matters is where you land when the game's over. And when the clock ran down on Tuesday night's "Dancing With the Stars" finale, the Green Bay Packer was the clear winner.

ABC

Donald Driver and Peta Murgatroyd celebrate as "Dancing With the Stars" champions on Tuesday.

After spending most of the season trailing just behind his fellow finalists?William Levy and Katherine Jenkins, Donald closed the gap (and then some) in the finals. A solid judge's pick routine on Monday night and his 24-hour-prep performance in the finale helped him, but it was no doubt his show-stopping, country-themed finals freestyle that sealed the deal when it came to viewer votes.

When the results were announced, Donald threw himself across the dance floor, as he's been apt to do during high-points all season long. Then host Tom Bergeron turned to the wide receiver and said, "I've got to ask you the question that Brooke (Burke Charvet) always asks: How do you feel?"

Completely ignoring that Brooke zinger, Donald raved, "Amazing! Oh, this is awesome! Thank you so much."

The victory was a sweet one for the man who spent much of the season hoping (and rehearsing) for a single perfect score from the panel -- and more importantly, from head judge Len Goodman. Donald regularly wished for a "10 from Len," and in the final 24 hours of the competition, he boasted two of them and a sparkling mirror ball trophy too.

Of course, the win wasn't just a victory for Donald. His partner, Peta Murgatroyd, is now a "Dancing" champ. After exiting the game in the first week during her premiere season, she took it all the way with Donald in her second effort.

Adam Taylor / ABC

Donald and Peta's win wasn't the only one of the night. OK, technically it was, but Donald's fellow finalists put on some praise-winning, if not show-winning performances.

First William, who ended the night in third place, took the floor for a salsa. It was a bold choice for his final routine after getting an earful from Len for performing a salsa-filled freestyle the night before. His last effort wasn't as polished as his earlier ones, but it still packed the hip-shaking and rear-rotating moves he's now known for.

Then second-place finisher Katherine took the floor for a jumping jive that earned raves from the panel. According to judge Bruno Tonioli, the dance only cemented the fact that she's "the girl that has it all."

Well, everything but a mirror ball trophy.

Donald's last-chance cha cha -- easily the best dance of the night, other than maybe his encore freestyle -- proved his win was well earned. The routine packed body rolls, smooth transitions and fan-pleasing perfect lines.

All the dances earned top scores from the panel.

And those weren't the only performances of note. The ballroom's past challengers of the season came back to remind the crowd just what they could do. Highlights included Sherri Shepherd's "It's Raining Men" routine, complete with pros Maksim Chmerkovskiy and Tony Dovolani raining from the ceiling while she took one last spin with Val Chmerkovskiy. And Melissa Gilbert hit the floor again with both Brothers Chmerkovskiy for a reworking of her memorable trio routine.

Roshon Fegan had the chance to show viewers what his freestyle would have looked like had he made it to the finals. The fast, content-packed dance was worth watching, but it seems a safe bet to say Donald would have still won that round.

But one of the most memorable performances of the night came from a not-so-great dancer -- Gladys Knight. The singing legend traded her dancing shoes for a microphone and belted out a tear-jerking rendition of "The Way We Were" while the finalists awaited the results.

That (and a whole lot of star-studded, clip-tastic filler) was all the two-hour finale could pack. But as Tom reminded viewers, the ballroom bash will be back in the fall with an all-star season bound to entertain fans once again.

What did you think of the finalists' last dances? Which returning star had the best performance? Share your thoughts on our Facebook page!

Did the right person win?

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Wednesday, May 23, 2012

Role of fusion gene in prostate cancer: Mutation found in half of all prostate cancers may lead to disease development

ScienceDaily (May 22, 2012) ? Up to half of all prostate cancer cells have a chromosomal rearrangement that results in a new "fusion" gene and formation of its unique protein -- but no one has known how that alteration promotes cancer growth. Now, Weill Cornell Medical College researchers have found that in these cancer cells, the 3-D architecture of DNA, wrapped up in a little ball known as a chromatin, is warped in such a way that a switch has been thrown on thousands of genes, turning them on or off to promote abnormal, unchecked growth. Researchers also found that new chromosomal translocations form, further destabilizing the genome.

These findings, published in the Proceedings of the National Academy of Sciences (PNAS), are the first to show how this chromosomal mutation likely contributes to early development of prostate cancer -- and suggests a model for how other chromosomal translocations, common to many tumor types, are linked to cancer formation and growth.

"This is likely a phenomenon that occurs in many types of cancers when oncogenic fusion genes are over-expressed," says the study's senior author, Dr. Mark A. Rubin, The Homer T. Hirst Professor of Oncology in Pathology and vice chair for experimental pathology at Weill Cornell Medical College.

Dr. Rubin adds that if such an oncogenic protein has the power to throw the switch on thousands of genes, a novel treatment may be able to turn that switch off. "If we understand how this works, then we may be able to borrow that trick to target many genes simultaneously. This discovery would hold a lot of promise for cancer therapy," he says.

The study also adds to the growing understanding of how remodeling of the chromatin regulates genes linked to cancer, says the study's lead author, Dr. David S. Rickman, assistant professor of pathology and laboratory medicine at Weill Cornell Medical College. The genome's DNA, along with specialized proteins, has to be packed into the chromatin bundle so that it can fit inside a cell's nucleus, and when genes need to be expressed, the chromatin opens up a bit, allowing transcription. Emerging evidence suggests that, within this package, the genome organizes itself according to a non-randomly-assembled, 3-D architecture of hubs and domains that affect when and where individual genes are turned on.

This study shows the oncogenic ERG protein, produced by the ETS prostate cancer fusion gene, binds to specific sites in the genome, which then forces the 3-D genome architecture to vastly change, creating different hubs and domains, Dr. Rickman says. This results in additional chromosomal translocations, as well as a coordinated expression of genes known to be relevant to aggressive prostate cancer, he says.

The research shows just how complex genetic regulation really is and how distortions in this process can lead to cancer, says Dr. Rubin, who is also a professor of pathology and laboratory medicine and professor of pathology in urology at Weill Cornell Medical College.

"We used to think everything related to gene expression was linear, that one promoter affected the gene located right next to it," he says. "Now we are beginning to understand that what happens in the 3-D space of tightly bundled DNA is also important -- how DNA opens up and undergoes changes that efficiently turn on whole sets of genes that aren't located anywhere near each other."

It Takes a Village -- of Scientists

Reaching these findings required a collaborative team of scientists, says Dr. Rubin, who co-discovered the ETS fusion gene. For this project, he sought the expertise of Dr. Rickman and Dr. Olivier Elemento, an assistant professor in the Department of Physiology and Biophysics and assistant professor of computational genomics in the Institute for Computational Biomedicine at Weill Cornell Medical College, and a co-senior author of the paper. Dr. Elemento and his lab provided the expertise in computational biology and mathematical analysis needed to interpret the complex data produced by the experiments run by Dr. Rickman, his lab and members of the Rubin laboratory.

Joining them were nine other scientists from Weill Cornell Medical College, and two from Mount Sinai School of Medicine.

Dr. Elemento, Dr. Rickman and their laboratory colleagues used numerous techniques to understand the effect of the ERG oncoprotein. They first used an experimental technique called Hi-C to query chromatin interactions throughout the genome. "Chromatin interactions are inherently complex and it is easy to grasp why this is so," says Dr. Elemento. "There are about 25,000 known genes in the human genome therefore there are possibly 25,000 x 25,000 interactions between genes -- which is 625 million -- and that is only scratching the surface."

To treat the high volume of data the researchers needed to develop new statistical methods to detect chromatin interactions and the changes that occur when ERG is over-expressed.

Then, to understand why these chromatin interaction changes occurred in the first place -- what it is that ERG does to generate new interactions or abolish existing ones -- they performed additional experiments, which produced even more data. They used a technique called ChIP-seq to map where on the genome ERG likes to bind, and then used the RNA-seq tool to determine which genes are expressed or shut down when ERG is present.

More analyses were needed to identify genes and regions on the genome whose interaction patterns changed most when ERG was over-expressed. Finally, they reached what Dr. Elemento called a shocking revelation: "ERG binds very often near the genes whose interaction patterns change the most, thus indicating that ERG directly mediates the interaction by binding to these regions."

The researchers then discovered that genes whose expression was collectively increased or shut down, and which were involved in chromatin interactions, were those that are involved in cell invasion, a key feature of aggressive prostate cancer. "We thus think that ERG may contribute to prostate cancer phenotype by rearranging chromatin interactions to promote the expression of these key malignancy genes," Dr. Elemento says.

ERG also seems to push the formation of new chromosomal translocations, he says. "This is exciting because it points to a completely novel, non-transcriptional role for ERG in cancer," Dr. Elemento says. "We think that it is possible that many genes like ERG -- which bind to the DNA -- could promote the formation of novel genetic alterations by rearranging chromatin interactions."

Dr. Rickman agrees, "These findings extend beyond the context of the prostate as many driving genetic lesions in other cancer types involve abnormal expression of transcription factors due to genomic alterations."

The researchers are now conducting studies to unravel the mechanism that accounts for these architectural changes. "Achieving this will provide a new understanding of cancer and novel ways to treat and prevent its progression," Dr. Rickman says.

The work was supported by funding from a U.S. Department of Defense New Investigator Award, a National Science Foundation CAREER Grant, a National Institutes of Health National Cancer Institute Grant and by the Starr Cancer Consortium.

Other co-authors include Dr. T. David Soong, Benjamin Moss, Dr. Juan Miguel Mosquera, Jan Dlabal, Dr. St?phane Terry, Theresa Y. MacDonald, Dr. Karen Bunting, Dr. Francesca Demichelis and Dr. Ari M. Melnick from Weill Cornell Medical College; and Joseph Tripodi and Dr. Vesna Najfeld from Mount Sinai School of Medicine.

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The above story is reprinted from materials provided by NewYork-Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. D. S. Rickman, T. D. Soong, B. Moss, J. M. Mosquera, J. Dlabal, S. Terry, T. Y. MacDonald, J. Tripodi, K. Bunting, V. Najfeld, F. Demichelis, A. M. Melnick, O. Elemento, M. A. Rubin. Oncogene-mediated alterations in chromatin conformation. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1112570109

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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